2-Methyltetrahydrofuran (MeTHF), An alternative to Tetrahydrofuran and Dichloromethane
is a versatile aprotic solvent that is an excellent replacement for tetrahydrofuran (THF) in Grignard and other organometallic reactions. MeTHF has a number of properties that make it a preferred solvent.
• Limited miscibility with water facilitates easy product recovery
• Can be easily dried with lower losses and lower recycle costs compared to THF
• Gives cleaner phase separations compared to processes that use solvent exchange of THF with toluene
• Especially useful for producing high concentrations of homogeneous solutions of bromo Grignard reagents
• Gives high yields of benzyl and allyl Grignard reagents
• Gives improved yields of addition product in systems where THF gives high yields of reduction product
• Permits higher reaction temperature and lower losses from reactor condensers
MeTHF has been found to be a very effective solvent for biphasic reactions, especially for reactions with aqueous NaOH such as alkylation, amidation and nucleophilic substitution reactions. MeTHF gives clean phase separations in these reactions and high reactivity.
Features & Benefits
Quickly produces clean water phase splits (density of 0.86 g/mL at 25°C) without forming emulsions unlike THF (Tetrahydrofuran) or DCM (Dichloromethane)
More easily dried than THF or DCM
Very stable even in highly acidic environments
Non-reactive, aprotic polar solvent
Forms an effective azeotrope with water
Higher boiling point (78-80°C)
Lower solvent loss during reflux
Allows rapid formation of Grignard reactants
Suitable replacement in most organometallic reactions where THF is used including Suzuki Coupling reactions
2-Methyltetrahydrofuran Monthly output: 20MT. Welcome to visit our 2-Methyltetrahydrofuran factory.
