(Z)-Guggulsterone CAS:95975-55-6CAS number : 95975-55-6

Chemical Name : (Z)-Guggulsterone

Application : Agrochem or Pharmaceutical intermediates

Product Information
Structural Formula
Synonym (Z)-Guggulsterone
Specifications Upon request
Packing See details
Material Safety Data Sheet Upon request
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Product Description:

CAS No: 95975-55-6
Product Name: (Z)-Guggulsterone
Other Name:
Density: 1.1±0.1 g/cm3
Boiling Point: 463.3±45.0 °C at 760 mmHg
Molecular Formula: C21H28O2
Molecular Weight: 312.446
Flash Point: 172.3±25.7 °C
Exact Mass: 312.208923
PSA: 34.14000
LogP: 3.65
Vapour Pressure: 0.0±1.1 mmHg at 25°C
Index of Refraction: 1.557
Storage condition: 2-8°C
Water Solubility: DMSO: 5 mg/mL
Appearance: White to off-whtie powder 
Assay: ≥99%
Residue on ignition: ≤0.1%
Loss on drying: ≤0.5% 
Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt. Guggulsterone, a farnesoid X receptor (FXR) antagonist, decreases CDCA-induced FXR activation with IC50s of 17 and 15 μM for Z- and E-Guggulsterone, respectively.
Package: 25kg/drum, can also be designed according to customer requirements.
Storage: Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

We offer a wide range of custom synthesis and production services for pharmaceutical intermediates, reference compounds and new reagents for pharmaceutical companies, pharmaceutical biotech companies, universities and research institutions.Our company has a 2000 square meter R&D center. The company's production base is mainly located in Liaocheng City, Shandong Province, Yuncheng City, Shanxi Province.In the complete production service chain with gram-kg-ton class, it can realize rapid response in the product development- pilot-amplification process and quickly transform technology into production.We are supplier of ingredients used in a large variety of applications. We have extensive product offerings, technical services and support, and a qualified sales team ready to deliver smart solutions for your specific needs.We have refined line design and route optimization and are committed to providing timely and efficient customization services. At the same time, we are experienced in multi-step synthesis, heterocyclic compounds, chiral compounds, sugar compounds.

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