CAS No: 95975-55-6
Product Name: (Z)-Guggulsterone
Density: 1.1±0.1 g/cm3
Boiling Point: 463.3±45.0 °C at 760 mmHg
Molecular Formula: C21H28O2
Molecular Weight: 312.446
Flash Point: 172.3±25.7 °C
Exact Mass: 312.208923
Vapour Pressure: 0.0±1.1 mmHg at 25°C
Index of Refraction: 1.557
Storage condition: 2-8°C
Water Solubility: DMSO: 5 mg/mL
Appearance: White to off-whtie powder
Residue on ignition: ≤0.1%
Loss on drying: ≤0.5%
Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt. Guggulsterone, a farnesoid X receptor (FXR) antagonist, decreases CDCA-induced FXR activation with IC50s of 17 and 15 μM for Z- and E-Guggulsterone, respectively.
Package: 25kg/drum, can also be designed according to customer requirements.
Storage: Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
We offer a wide range of custom synthesis and production services for pharmaceutical intermediates, reference compounds and new reagents for pharmaceutical companies, pharmaceutical biotech companies, universities and research institutions.Our company has a 2000 square meter R&D center. The company's production base is mainly located in Liaocheng City, Shandong Province, Yuncheng City, Shanxi Province.In the complete production service chain with gram-kg-ton class, it can realize rapid response in the product development- pilot-amplification process and quickly transform technology into production.We are supplier of ingredients used in a large variety of applications. We have extensive product offerings, technical services and support, and a qualified sales team ready to deliver smart solutions for your specific needs.We have refined line design and route optimization and are committed to providing timely and efficient customization services. At the same time, we are experienced in multi-step synthesis, heterocyclic compounds, chiral compounds, sugar compounds.
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Laboratory in Ningbo
Our company's R&D company, Ningbo Gino Chemical Co., Ltd. was established in December 2011. we have several fume hoods and kilogram laboratory, and have purchased 20L, 50L reactors and as a preliminary pilot manufacturing of the products. At the same time, We mobilized external resources to establish a pilot facility in Henan Zhumadian and Anhui Anqing, and cooperating with Shandong Zibo and Jiangsu Changzhou factories as a large production facility for our products.
Factory in Shanxi Province
At the end of 2017, We invested workshop in Xinjiang County Longzhou Chemical Co., Ltd., Xinjiang County Coal Mine Park, Yuncheng, Shanxi. The first phase of the reactors were 30* 2000L~5000L, The contract output value is 50 million annually, factory has passed the audit from public listed company domestic and abroad.
Factory in Shandong Province
The production base of liquid rectification chemical products located in Liaocheng, Shandong Province is the main outsourcing production base of our company. The products are sold to leading enterprises and listed companies in the carcass industry for many years. The production, quality and service are stable, delivery is timely, and some individual products are covering 90% of the market.
Factory in Henan Province
In year 2020, We invested workshop in Henan province, the workshop consists of 50*2000L~5000L reactors, The types of reactions that can be manufacturer there are: bromination, cyanidation, and conventional reactions.
Disclaimer: Certain products are for research use only. Not for diagnostic or therapeutic use. Not for human use. INNOPHARMCHEM does not sell to individuals. INNOPHARMCHEM does not warrant that the use or sale of the products delivered under will not infringe the claims of any China or other patents covering the product itself or the use thereof in combination with other products or the operation of any process.
| (E)-Guggulsterone CAS:39025-24-6